Documents submitted to the FDA’s CBER and CDER must comply with the agency’s PDF specifications regarding link appearance.
Both agencies prefer blue text for hyperlinks in PDFs created from electronic source files. For scanned documents, hyperlinks should be a thin blue line.
|Electronic Source File
If you are creating documents in Microsoft Word, it is best to style the text blue, or edit your styles to include the color, then convert to PDF.
Regulatory professionals often have to work with scanned documents, or PDFs authored outside of their control. For these documents, a post-process is required to bring link appearance into compliancy.
In this article, I’ll discuss how to change link color and style.