I cannot tell you how many times I have heard this question from new users to Studio 8. Its a very difficult question to answer as you must be aware of all the limitations of HTML and CSS to fully grasp and understand the concept of Web Design.
There are many workflows that I cannot describe in one shot about this process and felt Zoe Gillenwater’s article is an excellent read. Being someone that prefers to give everything away for free, the article actually costs 3.00(USD) to read, but I have to say its one of the best articles I’ve seen yet that can help get someone new to the process to get on the right track.
It’s not often I recommend a tutorial that costs money, but if you can spare the 3 bucks and you are a new user, then go get this article and tear it apart.
A CSS Web Design Case Study: Constructing a Personal Site – Slicing the Comp