Ryan Marples of Salesforce.com announced on the Force.com developer blog that an update is available to the Force.com Toolkit for Adobe Flex and AIR. This toolkit is designed from the ground up to make it easy to build engaging applications with Flex and Adobe AIR that, for example, allow users to access their Salesforce.com data and business processes when they are offline. Salesforce.com published a tutorial titled Taking Salesforce Data Offline Using Adobe AIR that describes how to build an AIR application that interfaces with Salesforce.com using this toolkit.
From the Force.com Toolkit for Adobe Flex and AIR wiki:
With the toolkit, Flex developers now have direct access to the Force.com Web services API, allowing the easy creation of new user experiences and web applications that connect directly to Force.com’s database, logic and workflow capabilities. And using the Adobe AIR component in the toolkit, information from Force.com can automatically be made available offline, allowing developers to extend their Force.com applications with offline and desktop applications.