If you are working with Designer on terminal server, you may experience intermittent problems starting the Designer client, such as the following error:
Unable to initialize ACE interface
Designer 6 or 7 are not supported on Terminal Server. Designer versions 8 and later are supported on terminal server.
There is an ACE.dll in the designer product folder, which is the Adobe Colour Engine.
As a workaround, you can copy the ace.dll from the Reader/Acrobat installation folder, and overwrite the one in the Designer folder. Make a backup of the Designer ACE.dll first. This has been known to resolve the issue for some customers.