While officially unsupported by Adobe, customers are successfully virtualizing Adobe Reader using App-V. If you’re looking to do this kind of thing, check out the beta of Microsoft’s TechNet Gallery. At the time of this post, there are package accelerators for Adobe Reader versions 9 and X.
Note: I have no personal experience with these package accelerators so I can’t make any claims to their usefulness, I’m just passing on the information. Please use the “Q and A” section of the specific package accelerator to post your questions and be sure to hand out some star ratings if they work for you.
Find all of the Package Accelerators for Adobe software in the Microsoft TechNet Gallery.