I've mentioned before that I do a large number of presenations using Adobe Acrobat Connect Professional. I have also used the Adobe Presenter to turn some of my static Powerpoint presentations into interactive, voiced-over presentations with Q and A built in.
Something I've been meaning to learn about is Adobe Captivate and I've heard that the latest version, Adobe Captivate 3 was announced yesterday.
Adobe Captivate 3 software allows you to rapidly create "powerful and engaging" simulations, scenario-based training, and quizzes without programming knowledge or multimedia skills. It's based on Adobe Flash software and Captivate 3 automatically generates interactive, Adobe Flash Player content for easy online distribution and access.
I feel the need to run a late night install and have a play.